Integrated Metabolomics and Proteomics Analysis Revealed Second Messenger System Disturbance in Hippocampus of Chronic Social Defeat Stress Rat

Integrated Metabolomics and Proteomics Analysis Revealed Second Messenger System Disturbance in Hippocampus of Chronic Social Defeat Stress Rat

Depression is a common and disabling mental disorder characterized by high disability and mortality, but its physiopathology remains unclear. In this study, we combined a non-targeted gas chromatography-mass spectrometry (GC-MS)-based metabolomic approach and isobaric tags for relative and absolute...

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Bibliographic Details
Main Authors: Li-Ning Yang, Jun-Cai Pu, Lan-Xiang Liu, Guo-Wei Wang, Xin-Yu Zhou, Yu-Qing Zhang, Yi-Yun Liu, Peng Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neuroscience
Subjects:
depression
social defeat
proteomics
metabolomics
second-messenger
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00247/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00247/full

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