OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence

OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence

Ovarian cancer (OC) is the most aggressive gynecological tumor worldwide and, notwithstanding the increment in conventional treatments, many resistance mechanisms arise, this leading to cure failure and patient death. So, the use of novel adjuvant drugs able to counteract these pathways is urgently...

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Bibliographic Details
Main Authors: Francesca Megiorni, Simona Camero, Paola Pontecorvi, Lucrezia Camicia, Francesco Marampon, Simona Ceccarelli, Eleni Anastasiadou, Nicola Bernabò, Giorgia Perniola, Antonio Pizzuti, Pierluigi Benedetti Panici, Vincenzo Tombolini, Cinzia Marchese
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
BET inhibitors
OTX015
ovarian cancer
GNL3 (nucleostemin)
radioresistance
Online Access:https://www.mdpi.com/2072-6694/13/7/1519

Internet

https://www.mdpi.com/2072-6694/13/7/1519

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