Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection

Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection

Abstract Background Viral infection activates innate immune pathways and interferons (IFNs) play a pivotal role in the outcome of a viral infection. Ubiquitin modifications of host and viral proteins significantly influence the progress of virus infection. Ubiquitin-conjugating enzyme E2s (UBE2) hav...

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Bibliographic Details
Main Authors: Tingting Feng, Lei Deng, Xiaochuan Lu, Wen Pan, Qihan Wu, Jianfeng Dai
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Virology Journal
Subjects:
UBE2J1
Dengue virus
Interferons
IRF3
K48 ubiquitination
Online Access:http://link.springer.com/article/10.1186/s12985-018-1040-5

Internet

http://link.springer.com/article/10.1186/s12985-018-1040-5

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