Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols

Human tyrosyl-DNA phosphodiesterase 1 (TDP1) belongs to the phospholipase D superfamily, whose members contain paired catalytic histidine and lysine residues within two conserved motifs and hydrolyze phosphodiester bonds. TDP1 is a DNA repair enzyme that processes 3′ DNA end blocking lesions and a w...

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Bibliographic Details
Main Authors: Nadezhda Dyrkheeva, Rashid Anarbaev, Natalia Lebedeva, Maxim Kuprushkin, Alexandra Kuznetsova, Nikita Kuznetsov, Nadejda Rechkunova, Olga Lavrik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tyrosyl-DNA phosphodiesterase 1
3′-phosphoglycolate
glycerol
alcohol
ethanol
spinocerebellar ataxia with axonal neuropathy type 1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.604732/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.604732/full

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