The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein

The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein

Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly. Using a human stem cell-derived neural progenitor model system, we find that a critical cellular quality control process called the nonsense-mediated m...

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Bibliographic Details
Main Authors: Krystal A. Fontaine, Kristoffer E. Leon, Mir M. Khalid, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia A. Kaye, Priya S. Shah, Steve Finkbeiner, Nevan J. Krogan, Melanie Ott
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
Zika virus
nonsense-mediated mRNA decay pathway
virus-host interactions
Online Access:https://doi.org/10.1128/mBio.02126-18

Internet

https://doi.org/10.1128/mBio.02126-18

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