NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases

NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases

The hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative conditions whose characteristic feature is degeneration of the longest axons within the corticospinal tract which leads to progressive spasticity and weakness of the lower limbs. Though highly genetically heterogene...

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Bibliographic Details
Main Authors: Philippa C. Fowler, M. Elena Garcia-Pardo, Jeremy C. Simpson, Niamh C. O’Sullivan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
endoplasmic reticulum
axon
mitochondria
lipid droplet
endolysosome
plasma membrane
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01051/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01051/full

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