Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.

Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.

Despite promising preclinical studies, oncolytic viral therapy for malignant gliomas has resulted in variable, but underwhelming results in clinical evaluations. Of concern are the low levels of tumour infection and viral replication within the tumour. This discrepancy between the laboratory and the...

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Bibliographic Details
Main Authors: Franz J Zemp, Brienne A McKenzie, Xueqing Lun, Lori Maxwell, Karlyne M Reilly, Grant McFadden, V Wee Yong, Peter A Forsyth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3675064?pdf=render

Internet

http://europepmc.org/articles/PMC3675064?pdf=render

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