E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway

E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway

Abstract Background The E2A gene, which encodes two basic helix–loop–helix transcription factors, E12 and E47, regulates colorectal cancer progression and epithelial-mesenchymal transition. However, whether E2A regulates the tumor-initiating capacity of colorectal cancer is unclear. Thus, we have st...

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Bibliographic Details
Main Authors: Hongchao Zhao, Chunlin Zhao, Haohao Li, Danhua Zhang, Guanghui Liu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Helix–loop–helix protein e12
Helix-loop-helix protein e47
Transcription factors
Epithelial-mesenchymal transition
FoxM1 protein
Human
Online Access:http://link.springer.com/article/10.1186/s13046-019-1261-5

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http://link.springer.com/article/10.1186/s13046-019-1261-5

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