Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction

Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction

Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadhe...

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Bibliographic Details
Main Authors: Xiaoying Yao, Guanjun Dong, Yuzhen Zhu, Fenglian Yan, Hui Zhang, Qun Ma, Xingqin Fu, Xuehui Li, QingQing Zhang, Junfeng Zhang, Hui Shi, Zhaochen Ning, Jun Dai, Zhihua Li, Chunxia Li, Bo Wang, Jiankuo Ming, Yonghong Yang, Feng Hong, Xiangzhi Meng, Huabao Xiong, Chuanping Si
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
CD11b
macrophage
endotoxin shock
TLR4
LPS
leukadherin-1 (LA1)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00215/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00215/full

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