Setd4 controlled quiescent c-Kit+ cells contribute to cardiac neovascularization of capillaries beyond activation

Abstract Blood vessels in the adult mammal exist in a highly organized and stable state. In the ischemic heart, limited expansion capacity of the myocardial vascular bed cannot satisfy demands for oxygen supply and the myocardium eventually undergoes irreversible damage. The predominant contribution...

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Bibliographic Details
Main Authors: Sheng Xing, Jin-Ze Tian, Shu-Hua Yang, Xue-Ting Huang, Yan-Fu Ding, Qian-Yun Lu, Jin-Shu Yang, Wei-Jun Yang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91105-6