Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis

Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis

Lafora disease (LD) is the inherited progressive myoclonus epilepsy caused by mutations in either EPM2A gene, encoding the protein phosphatase laforin or the NHLRC1 gene, encoding the ubiquitin ligase malin. Since malin is an ubiquitin ligase and its mutations cause LD, it is hypothesized that impro...

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Bibliographic Details
Main Authors: Jaiprakash Sharma, Sudheendra N.R. Rao, Susarla Krishna Shankar, Parthasarathy Satishchandra, Nihar Ranjan Jana
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neurobiology of Disease
Subjects:
Lafora disease
Neuronatin
Malin
Ubiquitin ligase
Glycogen synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002117

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http://www.sciencedirect.com/science/article/pii/S0969996111002117

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