Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab

Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab

Introduction: Belimumab is a monoclonal antibody against soluble BLyS used for treatment of refractory Systemic Lupus Erythematosus (SLE). Although B cells are the main target of this therapy, a BLyS-dependent T cell activation pathway has also been demonstrated. The aim of the study is to analyze B...

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Bibliographic Details
Main Authors: Francesca Regola, Silvia Piantoni, Torsten Lowin, Silvia Archetti, Rossella Reggia, Rajesh Kumar, Franco Franceschini, Paolo Airò, Angela Tincani, Laura Andreoli, Georg Pongratz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
B lymphocyte
T lymphocyte
BLyS levels
belimumab
systemic lupus erythematosus
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00433/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00433/full

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