Intracisternal delivery of NFkappaB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.

Intracisternal delivery of NFkappaB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.

We have previously demonstrated disease-dependent gene delivery in the brain using an AAV vector responding to NFB activation as a probe for inflammatory responses. This vector, injected focally in the parenchyma prior to a systemic kainic acid (KA) injection mediated inducible transgene expression...

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Bibliographic Details
Main Authors: Olivier eBockstael, Liliane eTenenbaum, Deniz eDalkara, Catherine eMelas, Olivier eDe Witte, Marc eLevivier, Abdelwahed eChtarto
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Cerebrospinal Fluid
Cisterna Magna
Neuroinflammation
aav
inducible vector
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00092/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00092/full

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