Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral Vectors

Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral Vectors

Airway gene delivery is a promising strategy to treat patients with life-threatening lung diseases such as cystic fibrosis (CF). However, this strategy has to be evaluated in large animal preclinical studies in order to translate it to human applications. Because of anatomic and physiological simila...

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Bibliographic Details
Main Authors: Huibi Cao, Tiago N Machuca, Jonathan C Yeung, Jing Wu, Kai Du, Cathleen Duan, Kohei Hashimoto, Virginia Linacre, Allan L Coates, Kitty Leung, Jian Wang, Herman Yeger, Ernest Cutz, Mingyao Liu, Shaf Keshavjee, Jim Hu
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cystic fibrosis
lung gene delivery
pig
Online Access:http://www.sciencedirect.com/science/article/pii/S216225311630186X

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http://www.sciencedirect.com/science/article/pii/S216225311630186X

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