Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment

Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment

In ovarian cancer, upregulation of the Wnt/β−catenin pathway leads to chemoresistance and correlates with T cell exclusion from the tumor microenvironment (TME). Our objectives were to validate these findings in an independent cohort of ovarian cancer subjects and determine whethe...

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Bibliographic Details
Main Authors: Whitney N. Goldsberry, Selene Meza-Perez, Angelina I. Londoño, Ashwini A. Katre, Bryan T. Mott, Brandon M. Roane, Nidhi Goel, Jaclyn A. Wall, Sara J. Cooper, Lyse A. Norian, Troy D. Randall, Michael J. Birrer, Rebecca C. Arend
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
wnt
wnt inhibition
ovarian cancer
tumor microenvironment
id8 cells
id8p53<sup>−/−</sup> cells
murine ovarian cancer
cgx1321
porcn inhibitor
Online Access:https://www.mdpi.com/2072-6694/12/3/766

Internet

https://www.mdpi.com/2072-6694/12/3/766

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