COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma

COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma

The oxidative phosphorylation machinery in mitochondria, which generates the main bioenergy pool in cells, includes four enzyme complexes for electron transport and ATP synthase. Among them, the cytochrome <i>c</i> oxidase (COX), which constitutes the fourth complex, has been suggested a...

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Bibliographic Details
Main Authors: Yu-De Chu, Wey-Ran Lin, Yang-Hsiang Lin, Wen-Hsin Kuo, Chin-Ju Tseng, Siew-Na Lim, Yen-Lin Huang, Shih-Chiang Huang, Ting-Jung Wu, Kwang-Huei Lin, Chau-Ting Yeh
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
mitochondria
cytochrome <i>c</i> oxidase
U2 auxiliary factor homology motif kinase 1
bioenergy
extracellular signal-regulated kinase
Online Access:https://www.mdpi.com/2072-6694/12/6/1646

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https://www.mdpi.com/2072-6694/12/6/1646

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