Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils

Parkinson's disease is a debilitating neurodegenerative disorder that is pathologically characterized by intracellular inclusions comprised primarily of alpha-synuclein (αSyn) that can also be transmitted from neuron to neuron. Several lines of evidence suggest that these inclusions cause neuro...

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Bibliographic Details
Main Authors: Matthew Redmann, Willayat Y. Wani, Laura Volpicelli-Daley, Victor Darley-Usmar, Jianhua Zhang
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716304153