Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

Abstract Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigr...

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Main Authors: Jae Hoon Sul, Susan K. Service, Alden Y. Huang, Vasily Ramensky, Sun-Goo Hwang, Terri M. Teshiba, YoungJun Park, Anil P. S. Ori, Zhongyang Zhang, Niamh Mullins, Loes M. Olde Loohuis, Scott C. Fears, Carmen Araya, Xinia Araya, Mitzi Spesny, Julio Bejarano, Margarita Ramirez, Gabriel Castrillón, Juliana Gomez-Makhinson, Maria C. Lopez, Gabriel Montoya, Claudia P. Montoya, Ileana Aldana, Javier I. Escobar, Jorge Ospina-Duque, Barbara Kremeyer, Gabriel Bedoya, Andres Ruiz-Linares, Rita M. Cantor, Julio Molina, Giovanni Coppola, Roel A. Ophoff, Gabriel Macaya, Carlos Lopez-Jaramillo, Victor Reus, Carrie E. Bearden, Chiara Sabatti, Nelson B. Freimer
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-0758-1

Internet

https://doi.org/10.1038/s41398-020-0758-1

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