Neurotrophic, Cytoprotective, and Anti-inflammatory Effects of St. John's Wort Extract on Differentiated Mouse Hippocampal HT-22 Neurons

Neurotrophic, Cytoprotective, and Anti-inflammatory Effects of St. John's Wort Extract on Differentiated Mouse Hippocampal HT-22 Neurons

Introduction: Since ancient times Hypericum perforatum L. named St. John's wort (SJW), has been used in the management of a wide range of applications, including nervous disorders. Development of mood disorders are due to alterations in glutamate metabolism, initiation of inflammatory pathways,...

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Bibliographic Details
Main Authors: Gabriel A. Bonaterra, Anna Schwendler, Julian Hüther, Hans Schwarzbach, Anja Schwarz, Christiane Kolb, Heba Abdel-Aziz, Ralf Kinscherf
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
anti-inflammatory
differentiated hippocampal neurons
human macrophages
neuronal plasticity
NMDA/glutamate excitotoxicity
St. John's wort
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00955/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00955/full

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