Multi-scale modeling identifies the role of p53-Gys2 negative feedback loop in cellular homeostasis

Multi-scale modeling identifies the role of p53-Gys2 negative feedback loop in cellular homeostasis

The transcription factor p53 is a tumor suppressor and strictly controlled p53 protein abundance coordinates cellular outcomes in response to various stresses. The glycogen synthase 2 (Gys2) and p53 generates a novel negative feedback circuit in which p53 represses Gys2 expression whereas Gys2 can s...

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Bibliographic Details
Main Authors: Tingzhe Sun, Dan Mu
Format: Article
Language:English
Published: AIMS Press 2020-05-01
Series:Mathematical Biosciences and Engineering
Subjects:
p53-gys2
negative feedback loop
hepatocellular carcinoma
robustness
tunability
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2020186?viewType=HTML

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https://www.aimspress.com/article/doi/10.3934/mbe.2020186?viewType=HTML

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