Multi-scale modeling identifies the role of p53-Gys2 negative feedback loop in cellular homeostasis
The transcription factor p53 is a tumor suppressor and strictly controlled p53 protein abundance coordinates cellular outcomes in response to various stresses. The glycogen synthase 2 (Gys2) and p53 generates a novel negative feedback circuit in which p53 represses Gys2 expression whereas Gys2 can s...
Main Authors: | Tingzhe Sun, Dan Mu |
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Format: | Article |
Language: | English |
Published: |
AIMS Press
2020-05-01
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Series: | Mathematical Biosciences and Engineering |
Subjects: | |
Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2020186?viewType=HTML |
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