Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma

Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma

Cholinergic signaling via the muscarinic M3 acetylcholine receptor (M3R) is involved in the development and progression of colorectal cancer (CRC). The present study aimed to analyze the blocking of M3R signaling in CRC using darifenacin, a selective M3R antagonist. Darifenacin effects were studied...

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Bibliographic Details
Main Authors: Nina A. Hering, Verena Liu, Rayoung Kim, Benjamin Weixler, Raoul A. Droeser, Marco Arndt, Ioannis Pozios, Katharina Beyer, Martin E. Kreis, Hendrik Seeliger
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
colorectal cancer
acetylcholine
muscarinic acetylcholine receptor
cholinergic signaling
darifenacin
matrix metalloproteinase 1
Online Access:https://www.mdpi.com/2072-6694/13/13/3220

Internet

https://www.mdpi.com/2072-6694/13/13/3220

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