Cigarette smoke induction of Interleukin-27/WSX-1 regulates the differentiation of Th1 and Th17 cells in a smoking mouse model of emphysema

Cigarette smoke induction of Interleukin-27/WSX-1 regulates the differentiation of Th1 and Th17 cells in a smoking mouse model of emphysema

IFN-γ-producing CD4+T (Th1) cells and IL-17-producing CD4+T (Th17) cells play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immune regulation between Th1 and Th17 cells remains unclear. Previous studies have demonstrated that IL-27/WSX-1 exerted pr...

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Bibliographic Details
Main Authors: Shi-Lin Qiu, Min-Chao Duan, Yi Liang, Hai-Juan Tang, Guang-Nan Liu, Liang-Ming Zhang, Chao-Mian Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Th1 Cells
Th17 Cells
COPD
Cigarette smoke exposure
IL-27/WSX-1
smoking mouse model of emphysema
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00553/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00553/full

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