Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life

Abstract Epigenetic imprinting is important for neurogenesis and brain function. Hippocampal volumes and brain hyperintensities in late life have been associated with early life circumstances. Epigenetic imprinting may underpin these associations. Methylation was measured at 982 sites in 13 imprinte...

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Bibliographic Details
Main Authors: Marlene Lorgen-Ritchie, Alison D. Murray, Roger Staff, Anne C. Ferguson-Smith, Marcus Richards, Graham W. Horgan, Louise H. Phillips, Gwen Hoad, Chris McNeil, Antonio Ribeiro, Paul Haggarty
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78062-2