STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass.

STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass.

BACKGROUND: Cardiopulmonary bypass (CPB) surgery initiates a controlled systemic inflammatory response characterized by a cytokine storm, monocytosis and transient monocyte activation. However, the responsiveness of monocytes to Toll-like receptor (TLR)-mediated activation decreases throughout the p...

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Bibliographic Details
Main Authors: Petrus R de Jong, Alvin W L Schadenberg, Theo van den Broek, Jeffrey M Beekman, Femke van Wijk, Paul J Coffer, Berent J Prakken, Nicolaas J G Jansen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3323636?pdf=render

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http://europepmc.org/articles/PMC3323636?pdf=render

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