Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.

Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.

The neuropathology of Parkinson's disease (PD) includes loss of dopaminergic neurons in the substantia nigra, nitrated alpha-synuclein (N-alpha-Syn) enriched intraneuronal inclusions or Lewy bodies and neuroinflammation. While the contribution of innate microglial inflammatory activities to dis...

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Bibliographic Details
Main Authors: Eric J Benner, Rebecca Banerjee, Ashley D Reynolds, Simon Sherman, Vladimir M Pisarev, Vladislav Tsiperson, Craig Nemachek, Pawel Ciborowski, Serge Przedborski, R Lee Mosley, Howard E Gendelman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2147051?pdf=render

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http://europepmc.org/articles/PMC2147051?pdf=render

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