A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

Ribosome biogenesis is a complex and energy-demanding process requiring tight coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given the extremely high level of RP synthesis in rapidly growing cells, alteration of any step in the ribosome assembly process may impact growth...

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Bibliographic Details
Main Authors: Benjamin Albert, Isabelle C Kos-Braun, Anthony K Henras, Christophe Dez, Maria Paula Rueda, Xu Zhang, Olivier Gadal, Martin Kos, David Shore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
ribosome biogenesis
ribosomal protein
heat shock factor 1
Ifh1
topoisomerase
protein aggregation
Online Access:https://elifesciences.org/articles/45002

Internet

https://elifesciences.org/articles/45002

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