NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells

NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells

Summary: Sustained activation of the Ca2+-release-activated Ca2+ (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of ORAI1, the pore subunit of CRAC channels, is limited in effec...

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Bibliographic Details
Main Authors: Beibei Wu, Jin Seok Woo, Pamela Vila, Marcus Jew, Jennifer Leung, Zuoming Sun, Sonal Srikanth, Yousang Gwack
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
ORAI1, STIM1, T cell receptor signaling, NKD2, CRAC channels, effector T cells, store-operated calcium entry, intracellular vesicles
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472101041X

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http://www.sciencedirect.com/science/article/pii/S221112472101041X

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