SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-25015-6 |