Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration

Increasing evidence suggests that neurodegenerative disorders share a common pathogenic feature: the presence of deposits of misfolded proteins with altered physicochemical properties in the Central Nervous System. Despite a lack of infectivity, experimental data show that the replication and propag...

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Bibliographic Details
Main Authors: Carlo Scialò, Elena De Cecco, Paolo Manganotti, Giuseppe Legname
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/11/3/261