Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

Planar supported lipid bilayers (PSLB) presenting T cell receptor (TCR) ligands and ICAM-1 induce budding of extracellular microvesicles enriched in functional TCR, defined here as synaptic ectosomes (SE), from helper T cells. SE bind peptide-MHC directly exporting TCR into the synaptic cleft, but i...

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Bibliographic Details
Main Authors: David G Saliba, Pablo F Céspedes-Donoso, Štefan Bálint, Ewoud B Compeer, Kseniya Korobchevskaya, Salvatore Valvo, Viveka Mayya, Audun Kvalvaag, Yanchun Peng, Tao Dong, Maria-Laura Tognoli, Eric O'Neill, Sarah Bonham, Roman Fischer, Benedikt M Kessler, Michael L Dustin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
extracellular vesicles
CRISPR/Cas9
immune synapse
CD40L
ICOS
tetraspanins
Online Access:https://elifesciences.org/articles/47528

Internet

https://elifesciences.org/articles/47528

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