SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response

SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response

Binding of antigen to IgE-high affinity FcεRI complexes on mast cells and basophils results in the release of preformed mediators such as histamine and de novo synthesis of cytokines causing allergic reactions. Src-like adapter protein (SLAP) functions co-operatively with c-Cbl to negatively regulat...

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Bibliographic Details
Main Authors: Namit Sharma, Marta Ponce, Savar Kaul, Zhongda Pan, Donna M. Berry, Thomas Eiwegger, Catherine J. McGlade
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
IgE receptor
mast cell
basophil
signaling
Cbl-b
SLAP
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01020/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01020/full

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