Several different cytogenetic clones arising during treatment of Philadelphia positive chronic myeloid leukemia with tyrosine kinase inhibitors lead to the progression into Philadelphia negative acute myeloid leukemia

Several different cytogenetic clones arising during treatment of Philadelphia positive chronic myeloid leukemia with tyrosine kinase inhibitors lead to the progression into Philadelphia negative acute myeloid leukemia

Introduction. Additional karyotype abnormalities in the Philadelphia-positive (Ph+) clone can emerge during the progression of chronic myeloid leukemia (CML) and are of-ten associated with the resistance to treatment with tyrosine kinase inhibitors (TKI). Sometimes, during the TKI treatment, karyoty...

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Bibliographic Details
Main Authors: Denčić-Fekete Marija, Leković Danijela, Đorđević Vesna, Jovanović Jelica, Todorić-Živanović Biljana, Jaković Ljubomir, Bogdanović Andrija
Format: Article
Language:English
Published: Military Health Department, Ministry of Defance, Serbia 2021-01-01
Series:Vojnosanitetski Pregled
Subjects:
leukemia, myelogenous, chronic, bcr-abl positive
leukemia, myeloid, acute
karyotyping
enzyme inhibitors
cytogenetics
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900010D.pdf

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http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900010D.pdf

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