The effects of Andrographis paniculata (Burm.f.) Nees on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers

The effects of Andrographis paniculata (Burm.f.) Nees on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers

Andrographis paniculata (Burm.f.) Nees has been widely used for centuries in Asia for the treatment of common coldand diarrhea. Although it was previously reported to inhibit cytochrome P450 in vitro, the potential to cause herb-druginteraction has been questioned. The purpose of this study was to e...

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Bibliographic Details
Main Authors: Malinee Wongnawa, Potjanee Soontaro, Wibool Riditid, Payom Wongpoowarak, Suwit Ruengkittisakul
Format: Article
Language:English
Published: Prince of Songkla University 2012-11-01
Series:Songklanakarin Journal of Science and Technology (SJST)
Subjects:
Andrographis paniculata
andrographolide
midazolam
herb-drug interaction
CYP3A4
Online Access:http://rdo.psu.ac.th/sjstweb/journal/34-5/0475-3395-34-5-533-539.pdf

Internet

http://rdo.psu.ac.th/sjstweb/journal/34-5/0475-3395-34-5-533-539.pdf

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