The replicative CMG helicase: the ideal target for cancer therapy
This review focuses on Cdc45-Mcm2-7-GINS (CMG) helicase which is a key component of the cellular replication machinery and a new promising target for cancer therapy. In normal cells, only a small proportion of helicases becomes activated through the step-wise acquisition of all necessary subunits d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
2020-12-01
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| Series: | Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2020/12/Henderson_6_20.pdf |