The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity

The HIV 5′ Gag Region Displays a Specific Nucleotide Bias Regulating Viral Splicing and Infectivity

Alternative splicing and the expression of intron-containing mRNAs is one hallmark of HIV gene expression. To facilitate the otherwise hampered nuclear export of non-fully processed mRNAs, HIV encodes the Rev protein, which recognizes its intronic response element and fuels the HIV RNAs into the CRM...

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Bibliographic Details
Main Authors: Bastian Grewe, Carolin Vogt, Theresa Horstkötter, Bettina Tippler, Han Xiao, Bianca Müller, Klaus Überla, Ralf Wagner, Benedikt Asbach, Jens Bohne
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
HIV gene expression
U1 snRNP
mRNP code
alternative splicing
Online Access:https://www.mdpi.com/1999-4915/13/6/997

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https://www.mdpi.com/1999-4915/13/6/997

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