Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli

Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing Escherichia coli

A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF...

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Bibliographic Details
Main Authors: Vera Manageiro, David Félix, Daniela Jones-Dias, Daniel A. Sampaio, Luís Vieira, Luísa Sancho, Eugénia Ferreira, Manuela Caniça
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Microbiology
Subjects:
QepA4
quinolone resistance
genetic characterization
PaβN
WGS
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01899/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01899/full

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