Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis

Abstract Background Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has often been described as an oncoprotein that preferentially contributes to t...

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Bibliographic Details
Main Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang, Xiaoping Zou
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cell Communication and Signaling
Subjects:
cMyc
Pyruvate
HDAC3
Apoptosis
Cholangiocarcinoma
Online Access:http://link.springer.com/article/10.1186/s12964-019-0332-8

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http://link.springer.com/article/10.1186/s12964-019-0332-8

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