IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

The insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs/IGF2BPs) IMP1 and 3 are regarded as oncofetal proteins, whereas the hepatic IMP2 expression in adults is controversially discussed. The splice variant IMP2-2/p62 promotes steatohepatitis and hepatocellular carcinoma. Aim of this stu...

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Bibliographic Details
Main Authors: Beate Czepukojc, Ali Abuhaliema, Ahmad Barghash, Sascha Tierling, Norbert Naß, Yvette Simon, Christina Körbel, Cristina Cadenas, Noemi van Hul, Agapios Sachinidis, Jan G. Hengstler, Volkhard Helms, Matthias W. Laschke, Jörn Walter, Johannes Haybaeck, Isabelle Leclercq, Alexandra K. Kiemer, Sonja M. Kessler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Medicine
Subjects:
liver cancer
stem cell
de-differentiation
oval cell
HCC
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00179/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00179/full

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