Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review
Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out...
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doaj-40ea28896ef24cba9631edfe629a224b2021-06-30T23:31:49ZengMDPI AGNutrients2072-66432021-06-01131959195910.3390/nu13061959Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic ReviewFlora O. Vanoni0Gregorio P. Milani1Carlo Agostoni2Giorgio Treglia3Pietro B. Faré4Pietro Camozzi5Sebastiano A. G. Lava6Mario G. Bianchetti7Simone Janett8Family Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandPediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyPediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyAcademic Education, Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandDepartment of Internal Medicine, Ente Ospedaliero Cantonale, 6600 Locarno, SwitzerlandDepartment of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandPediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandFamily Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandDepartment of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandChronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I<sup>2</sup>-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.https://www.mdpi.com/2072-6643/13/6/1959magnesiumhypomagnesemiadepletionkidneydietalcohol-use |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Flora O. Vanoni Gregorio P. Milani Carlo Agostoni Giorgio Treglia Pietro B. Faré Pietro Camozzi Sebastiano A. G. Lava Mario G. Bianchetti Simone Janett |
spellingShingle |
Flora O. Vanoni Gregorio P. Milani Carlo Agostoni Giorgio Treglia Pietro B. Faré Pietro Camozzi Sebastiano A. G. Lava Mario G. Bianchetti Simone Janett Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review Nutrients magnesium hypomagnesemia depletion kidney diet alcohol-use |
author_facet |
Flora O. Vanoni Gregorio P. Milani Carlo Agostoni Giorgio Treglia Pietro B. Faré Pietro Camozzi Sebastiano A. G. Lava Mario G. Bianchetti Simone Janett |
author_sort |
Flora O. Vanoni |
title |
Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review |
title_short |
Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review |
title_full |
Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review |
title_fullStr |
Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review |
title_full_unstemmed |
Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review |
title_sort |
magnesium metabolism in chronic alcohol-use disorder: meta-analysis and systematic review |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-06-01 |
description |
Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I<sup>2</sup>-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion. |
topic |
magnesium hypomagnesemia depletion kidney diet alcohol-use |
url |
https://www.mdpi.com/2072-6643/13/6/1959 |
work_keys_str_mv |
AT floraovanoni magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT gregoriopmilani magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT carloagostoni magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT giorgiotreglia magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT pietrobfare magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT pietrocamozzi magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT sebastianoaglava magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT mariogbianchetti magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview AT simonejanett magnesiummetabolisminchronicalcoholusedisordermetaanalysisandsystematicreview |
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