LHPP suppresses colorectal cancer cell migration and invasion in vitro and in vivo by inhibiting Smad3 phosphorylation in the TGF-β pathway

LHPP suppresses colorectal cancer cell migration and invasion in vitro and in vivo by inhibiting Smad3 phosphorylation in the TGF-β pathway

Abstract The roles of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) in tumorigenesis have been recently proven in hepatocellular carcinoma (HCC), cervical, pancreatic, bladder, and thyroid cancers. Previous research demonstrated that LHPP repressed cell proliferation and...

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Bibliographic Details
Main Authors: Bin Hou, Wenhan Li, Peng Xia, Fengyu Zhao, Zhao Liu, Qingnuo Zeng, Shilong Wang, Dongmin Chang
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00657-z

Internet

https://doi.org/10.1038/s41420-021-00657-z

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