Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

<p>Abstract</p> <p>Mammalian target of rapamycin (mTOR) can be found in two multi-protein complexes, i.e. mTORC1 (containing Raptor) and mTORC2 (containing Rictor). Here, we investigated the mechanisms by which mTORC1 and mTORC2 are activated and their downstream targets in respons...

Full description

Bibliographic Details
Main Authors: Razmara Masoud, Heldin Carl-Henrik, Lennartsson Johan
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Cell Communication and Signaling
Subjects:
PDGF
PI3K
mTOR
Rictor
Raptor
Akt
PLC
PKC
PLD
S6
Online Access:http://www.biosignaling.com/content/11/1/3

Internet

http://www.biosignaling.com/content/11/1/3

Similar Items