Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB

Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB

The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a poorly understood cell toxicity. The dementia FENIB is caused by polymerisation of the neuronal serpin neuroserpin (NS) within the...

Full description

Bibliographic Details
Main Authors: Noemi A. Guadagno, Claudia Moriconi, Valerio Licursi, Emanuela D'Acunto, Paola S. Nisi, Nicoletta Carucci, Antonella De Jaco, Emanuele Cacci, Rodolfo Negri, Giuseppe Lupo, Elena Miranda
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Neurobiology of Disease
Subjects:
Neuroserpin
Serpin polymers
Familial encephalopathy with neuroserpin inclusion bodies
Protein conformational disease
Neurodegeneration
Neural progenitor cells
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730058X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611730058X

Similar Items