Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D

Lipid aldehydes including isolevuglandins (IsoLGs) and 4-hydroxynonenal modify phosphatidylethanolamine (PE) to form proinflammatory and cytotoxic adducts. Therefore, cells may have evolved mechanisms to degrade and prevent accumulation of these potentially harmful compounds. To test if cells could...

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Bibliographic Details
Main Authors: Lilu Guo, Stephen D. Gragg, Zhongyi Chen, Yongqin Zhang, Venkataraman Amarnath, Sean S. Davies
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
isoketal
N-acyl phosphatidylethanolamine
cytotoxicity
inflammation
oxidative stress
N-acyl ethanolamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350665

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http://www.sciencedirect.com/science/article/pii/S0022227520350665

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