Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA

Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA

Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.

Bibliographic Details
Main Authors: Ei-Wen Yang, Jae Hoon Bahn, Esther Yun-Hua Hsiao, Boon Xin Tan, Yiwei Sun, Ting Fu, Bo Zhou, Eric L. Van Nostrand, Gabriel A. Pratt, Peter Freese, Xintao Wei, Giovanni Quinones-Valdez, Alexander E. Urban, Brenton R. Graveley, Christopher B. Burge, Gene W. Yeo, Xinshu Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09292-w

Internet

https://doi.org/10.1038/s41467-019-09292-w

Similar Items