β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4

β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4

The chemokine receptor CXCR4 plays a fundamental role in homeostasis and pathology by orchestrating recruitment and positioning of immune cells, under the guidance of a CXCL12 gradient. The ability of chemokines to form heterocomplexes, enhancing their function, represents an additional level of reg...

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Bibliographic Details
Main Authors: Gianluca D’Agostino, Marc Artinger, Massimo Locati, Laurent Perez, Daniel F. Legler, Marco E. Bianchi, Curzio Rüegg, Marcus Thelen, Adriano Marchese, Marco B. L. Rocchi, Valentina Cecchinato, Mariagrazia Uguccioni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
cell migration
CXCR4
CXCL12
HMGB1
β-arrestin
CXCL12/HMGB1 heterocomplex
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.550824/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.550824/full

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