Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging

Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging

Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. Recent observations have shown that patients treated with MTX also exhibit a reduced risk for the development of cardiovascular disease (CVD). Although MTX reduces systemic inflammation and tissue dama...

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Bibliographic Details
Main Authors: Matthew C. Zimmerman, Dahn L. Clemens, Michael J. Duryee, Cleofes Sarmiento, Andrew Chiou, Carlos D. Hunter, Jun Tian, Lynell W. Klassen, James R. O’Dell, Geoffrey M. Thiele, Ted R. Mikuls, Daniel R. Anderson
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
Methotrexate
Malondialdehyde-Acetaldehyde (MAA) Adducts
Superoxide
Electron Paramagnetic Resonance (EPR) Spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717304974

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http://www.sciencedirect.com/science/article/pii/S2213231717304974

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