Impaired glutathione redox system paradoxically suppresses angiotensin II-induced vascular remodeling.

Impaired glutathione redox system paradoxically suppresses angiotensin II-induced vascular remodeling.

BACKGROUND: Angiotensin II (AII) plays a central role in vascular remodeling via oxidative stress. However, the interaction between AII and reduced glutathione (GSH) redox status in cardiovascular remodeling remains unknown. METHODS: In vivo: The cuff-induced vascular injury model was applied to Spr...

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Bibliographic Details
Main Authors: Kazuma Izawa, Motoi Okada, Kazuhiro Sumitomo, Naoki Nakagawa, Yoshiaki Aizawa, Junichi Kawabe, Kenjiro Kikuchi, Naoyuki Hasebe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4208744?pdf=render

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http://europepmc.org/articles/PMC4208744?pdf=render

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