Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such re...

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Bibliographic Details
Main Authors: Hua Liang, Liufu Deng, Yuzhu Hou, Xiangjiao Meng, Xiaona Huang, Enyu Rao, Wenxin Zheng, Helena Mauceri, Matthias Mack, Meng Xu, Yang-Xin Fu, Ralph R. Weichselbaum
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01566-5

Internet

https://doi.org/10.1038/s41467-017-01566-5

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