Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS

Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS

Dysregulation of the retinoic acid (RA) signaling pathway is observed in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here, we investigated the therapeutic potential of retinoid activation via the RA receptor β (RARβ) in the SOD1G93A mouse model of ALS. Our approach uti...

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Bibliographic Details
Main Authors: David X. Medina, Eugene P. Chung, Collin D. Teague, Robert Bowser, Rachael W. Sirianni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
amyotrophic lateral sclerosis (ALS)
retinoic acid signaling
nanoparticle
neurodegeneration and neuroprotection
drug delivery
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00224/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00224/full

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